abstract：BACKGROUND AND AIMS:MMP-7, a member of the matrix metalloproteinase family, is believed to play a significant role in the growth and proliferation of colon cancer cells. The aim of this study was to evaluate MMP-7 gene expression in comparison with MMP-1, MMP-3, and MMP-13 in patients with resectable rectal and colon c...

journal_title：International journal of colorectal disease

authors： Roeb E,Arndt M,Jansen B,Schumpelick V,Matern S

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might ...

journal_title：International journal of colorectal disease

authors： Trojan J,Brieger A,Raedle J,Weber N,Kriener S,Kronenberger B,Caspary WF,Zeuzem S

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:In acute or chronic inflammatory bowel disease (IBD) interferon gamma (IFNgamma) is still considered to be an important pro-inflammatory mediator. In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IE...

journal_title：International journal of colorectal disease

authors： Schlottmann K,Wachs FP,Grossmann J,Vogl D,Maendel M,Falk W,Schölmerich J,Andus T,Rogler G

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis. The molecular mechanisms underlying their activation in response to profibrogenic mediators, however, are largely unknown. Extending previous studies on the transcriptional regulation of PSC activation, we ha...

journal_title：International journal of colorectal disease

authors： Fitzner B,Sparmann G,Emmrich J,Liebe S,Jaster R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND AIMS:When assessing quality of care the outcome in terms of quality of life (QOL) is of major significance. This study examined QOL in IBD outpatients and the contribution of individual expectations and various other factors including disease activity. PATIENTS AND METHODS:The study included 306 outpati...

journal_title：International journal of colorectal disease

authors： Janke KH,Raible A,Bauer M,Clemens P,Meisner C,Häuser W,Steder-Neukamm U,Henrich G,Herschbach P,Gregor M,Klump B

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Anastomotic dehiscence following colorectal surgery is a significant cause of morbidity and mortality. Phenytoin has wound-healing promoting and collagenase inhibitory effects. This study assessed these effects on healing of experimental colonic anastomoses in a rat model. MATERIALS AND METHODS:Nin...

journal_title：International journal of colorectal disease

authors： Turan M,Saraydin SU,Canbay E,Karadayi K,Bulut E,Cetinkaya O,Elagöz S,Sen M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND AIMS:This study evaluated the postoperative complications and clinical results of restorative proctocolectomy without diverting ileostomy for ulcerative colitis. PATIENTS AND METHODS:One hundred selected patients had a hand-sewn ileal J-pouch anal anastomosis with mucosectomy using an ultrasonically act...

journal_title：International journal of colorectal disease

authors： Ikeuchi H,Shoji Y,Kusunoki M,Yanagi H,Noda M,Yamamura T

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Malignant cells often exhibit perturbations in the pattern of cytosine methylation. Hypermethylation of CpG islands has been extensively documented, but genome-wide hypomethylation is also a common feature of malignant cells. The bulk of cytosine methylation in the mammalian genome occurs on repetit...

journal_title：International journal of colorectal disease

authors： Suter CM,Martin DI,Ward RL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recru...

journal_title：International journal of colorectal disease

authors： Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Extrarenal retroperitoneal angiomyolipomas are benign tumours of mesenchymal tissue origin. The diagnosis of these tumours is usually based on the perioperative findings and confirmed by the resultant specimen's histology. The main differential diagnosis is liposarcoma, and accurate preoperative imaging comb...

journal_title：International journal of colorectal disease

authors： Neary P,Mathews R,Harries R,McDonald A,Monson JR

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Gastrointestinal cancers belong to the most important causes of cancer death in the Western world. Because cure can be achieved only by complete surgical removal of the tumor, and most patients have metastasis at the time point of diagnosis, the majority of patients receive chemotherapy. DISCUSSION:Indicati...

journal_title：International journal of colorectal disease

authors： Gieseler F,Rudolph P,Kloeppel G,Foelsch UR

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Rectocele is a common finding in patients with intractable evacuatory disorders. Although much rectocele surgery is conducted by gynecologists en passant with other forms of vaginal surgery, many reports lack appreciation of the importance of coincident anorectal symptoms, and do not report functional and cl...

journal_title：International journal of colorectal disease

authors： Zbar AP,Lienemann A,Fritsch H,Beer-Gabel M,Pescatori M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle. PATIENT AND METHODS:We ...

journal_title：International journal of colorectal disease

authors： García-Olmo D,García-Arranz M,García LG,Cuellar ES,Blanco IF,Prianes LA,Montes JA,Pinto FL,Marcos DH,García-Sancho L

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Evacuation disorders associated with a rectocele can be improved by rectocele repair. This study investigated whether anorectal function tests results change after rectocele repair. PATIENTS AND METHODS:Fourteen patients with 2nd or 3rd degree rectocele and evacuation disorder were treated by poste...

journal_title：International journal of colorectal disease

authors： Sloots CE,Meulen AJ,Felt-Bersma RJ

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Photodynamic therapy (PDT) is a new treatment modality for early esophageal neoplasia. With two absorption maxima in the visible light range (550 and 588 nm) hypericin is a very promising photosensitizer for PDT with incoherent light sources. We studied the effects of photosensitizing hypericin in b...

journal_title：International journal of colorectal disease

authors： Höpfner M,Maaser K,Theiss A,Lenz M,Sutter AP,Kashtan H,von Lampe B,Riecken EO,Zeitz M,Scherübl H

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity. CASE REPORT:We report an...

journal_title：International journal of colorectal disease

authors： Pascu M,Müller AR,Wiedenmann B,Dignass AU

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Anal abscess is a frequent acute proctological disorder and whether the underlying fistula should be treated at the same time when the abscess is drained remains controversial. We examined indications for drainage alone versus drainage plus fistulotomy in terms of recurrence and continence. PATIENT...

journal_title：International journal of colorectal disease

authors： Oliver I,Lacueva FJ,Pérez Vicente F,Arroyo A,Ferrer R,Cansado P,Candela F,Calpena R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND AIMS:We investigated expression of E-cadherin, beta-catenin, and c-erbB-2 in gastric cancer to identify molecular factor(s) relevant to development of liver metastasis, which is a frequent cause of mortality in gastric cancer patients. PATIENTS AND METHODS:We analyzed by immunohistochemistry and compare...

journal_title：International journal of colorectal disease

authors： Ougolkov A,Yamashita K,Bilim V,Takahashi Y,Mai M,Minamoto T

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The surgical management of advanced primary or recurrent rectal cancer may involve the lower ureter or ureterovesical junction. With unilateral involvement, reconstruction of the ureters with salvage of the ipsilateral renal function should be considered. PATIENTS AND METHODS:With optimal exposure ...

journal_title：International journal of colorectal disease

authors： Sugarbaker PH,Gutman M,Verghese M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Reduced fibrinolytic activity of the peritoneum seems to be the main cause of postoperative adhesions. This prospective randomized trial compared the peritoneal fibrinolytic activity between laparoscopic and conventional colorectal resection. METHODS:Parietal peritoneal biopsy specimens were taken ...

journal_title：International journal of colorectal disease

authors： Neudecker J,Junghans T,Ziemer S,Raue W,Schwenk W

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND AIMS:This pilot study examines whether single-dose intravenous metronidazole preoperatively is at least as effective as a broad-spectrum multi-drug regimen in preventing infection-related wound complications following excision of pilonidal sinuses with primary closure. PATIENTS AND METHODS:A double-blin...

journal_title：International journal of colorectal disease

authors： Chaudhuri A,Bekdash BA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Dextran sulfate sodium (DSS) induced colitis exhibits a predominantly NF-kappaB dependent proinflammatory cytokine profile and shares similarities with human inflammatory bowel disease (IBD). Lamina propria macrophages of IBD patients display elevated levels of NF-kappaB p65. Knowing the role of NF-...

journal_title：International journal of colorectal disease

authors： Spiik AK,Ridderstad A,Axelsson LG,Midtvedt T,Björk L,Pettersson S

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...

journal_title：International journal of colorectal disease

authors： Rudzki Z,Zazula M,Okoń K,Stachura J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND AIMS:This study determined correlations of clinical and manometric features with those of anal endosonography (AES). PATIENTS AND METHODS:Between 1996 and 1999 we examined 58 patients suffering from anal incontinence (AI) by AES using a linear probe and anorectal manometry following a standardized proto...

journal_title：International journal of colorectal disease

authors： Barthet M,Bellon P,Abou E,Portier F,Berdah S,Lesavre N,Orsoni P,Bouvier M,Grimaud JC

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND AIMS:To study whether there are differences in the immunohistochemical staining of CD8, CD45R0, and CD68 of immune cells in regional lymph node metastases from colorectal cancer that are of potential interest in prognostic prediction. MATERIALS AND METHODS:Analysis of archival specimens from 93 patients...

journal_title：International journal of colorectal disease

authors： Oberg A,Samii S,Stenling R,Lindmark G

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon. METHODS:Fisher rats received intracolonic administration (0.5 ml) of saline or acetic acid at lo...

journal_title：International journal of colorectal disease

authors： Kono T,Yoneda M,Ohara K,Ayabe T,Chisato N,Kohgo Y,Kasai S,Terano A,Taché Y

更新日期：2001-11-01 00:00:00

abstract：:Colonoscopy is the established method of surveillance of subjects at high risk of developing colorectal neoplasia. Its role in the surveillance of a population at moderate risk is less clear, however, as the procedure is expensive, time consuming and occasionally hazardous. The aim of this study was to estimate by cas...

journal_title：International journal of colorectal disease

authors： Lamah M,Norris J,Caffarey SM,Broughton M,Marks CG

更新日期：2001-09-01 00:00:00

abstract：:Little is known about the local influence of pneumoperitoneum on components of the peritoneal immune defense mechanisms. We investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model. Fifty male Sprague Dawley rats underwent laparotomy, CO2 pneumoperitoneum, helium...

journal_title：International journal of colorectal disease

authors： Gutt CN,Hollander D,Brier CH,Kim ZG,Lorenz M

更新日期：2001-08-01 00:00:00

abstract：:The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still are unknown, but the induction of apoptosis is one of the possible mechanisms. We attempted to demonstrate the role of mitogen-activated protein (MAP) kinases, generally considered to be important mediators of proliferat...

journal_title：International journal of colorectal disease

authors： Kim TI,Jin SH,Kim WH,Kang EH,Choi KY,Kim HJ,Shin SK,Kang JK

更新日期：2001-06-01 00:00:00

abstract：:Flat-type colorectal tumors have are being detected with increasing frequency. It has become clear that these flat lesions contain two subtypes; flat-elevated and depressed lesions. However, their clinicopathological features and roles in colorectal carcinogenesis remain obscure. We classified colorectal adenomas and ...

journal_title：International journal of colorectal disease

authors： Sakashita M,Aoyama N,Maekawa S,Kuroda K,Shirasaka D,Ichihara T,Kuroda Y,Minami R,Maeda S,Kasuga M

更新日期：2000-11-01 00:00:00

abstract：:We investigated sinusoidal blood flow and hepatic tissue oxygenation during portal vein occlusion in cirrhotic rat livers to examine the effect of cirrhosis on the properties of hepatic microvascular blood flow regulation. After 8 weeks of CCl4/phenobarbital sodium treatment to induce cirrhosis Sprague-Dawley rats wer...

journal_title：International journal of colorectal disease

authors： Mücke I,Richter S,Menger MD,Vollmar B

更新日期：2000-11-01 00:00:00

abstract：:Enterovesical fistula is a relatively rare condition in Crohn's disease. This study was undertaken to examine clinicopathological features and management of enterovesical fistula complicating Crohn's disease. Thirty patients with enterovesical fistula complicating Crohn's disease, treated between 1970 and 1997, were r...

journal_title：International journal of colorectal disease

authors： Yamamoto T,Keighley MR

更新日期：2000-08-01 00:00:00

abstract：:Recurrence of pilonidal sinus disease after surgical intervention is not a very rare problem although sophisticated reconstruction procedures have been developed. Recurrence is thought to be related to the anatomical status of the patients, i.e., depth of the intergluteal groove. Obese patients have deeper interglutea...

journal_title：International journal of colorectal disease

authors： Cubukçu A,Gönüllü NN,Paksoy M,Alponat A,Kuru M,Ozbay O

更新日期：2000-06-01 00:00:00

abstract：:This study assessed the value of common surface coil magnetic resonance imaging (MRI) in patients with evacuatory disorders including fecal incontinence and constipation. These findings were then compared with those from other standard physiological examinations and/or surgical findings. From July 1996 to June 1997, 1...

journal_title：International journal of colorectal disease

authors： Matsuoka H,Desai MB,Wexner SD,Adami C,Mavrantonis C,Nogueras JJ,Weiss EG,Billotti VL,Nakamura T

更新日期：2000-04-01 00:00:00

abstract：:Imbalances in epithelium-matrix interactions have been discussed as a pathomechanism in ulcerative colitis, causing a colonic mucosal barrier dysfunction. Laminin, the major noncollagenous component of the basement membrane, plays a role in epithelial basal lamina formation and promotes differentiation of human entero...

journal_title：International journal of colorectal disease

authors： Schmehl K,Florian S,Jacobasch G,Salomon A,Körber J

更新日期：2000-02-01 00:00:00

abstract：:Myositis of the skeletal muscle is a rare complication of inflammatory bowel disease. We report about a 33-year-old woman with quiescent ulcerative colitis known since 1995. She had suffered from recurring fever and pain in the thighs for about 4 weeks. Electromyography of quadriceps and deltoid muscles revealed myopa...

journal_title：International journal of colorectal disease

authors： Voigt E,Griga T,Tromm A,Henschel MG,Vorgerd M,May B

更新日期：1999-12-01 00:00:00

abstract：:Leukocyte emigration from blood to sites of inflammation involves sequential interaction of specific adhesion molecules expressed by both leukocytes and endothelial cells. The central steps in leukocyte-endothelial adhesive interactions are leukocyte rolling, sticking, and transmigration. This study investigated the e...

journal_title：International journal of colorectal disease

authors： Krieglstein CF,Anthoni C,Laukötter MG,Rijcken E,Spiegel HU,Senninger N,Schürmann G

更新日期：1999-11-01 00:00:00

abstract：:Cryosurgery is one of the palliative treatment options to decrease local symptoms due to rectal carcinoma. A total of 106 patients (aged 45-92 years) underwent palliative cryosurgery for primary rectal cancer. Inclusion criteria were prohibitive surgical risk, unresectability, distant metastases, patient refusal of su...

journal_title：International journal of colorectal disease

authors： Meijer S,Rahusen FD,van der Plas LG

更新日期：1999-08-01 00:00:00

abstract：:We assessed the reliability of anorectal angle (ARA) measurement as an index of fecal incontinence. The "posterior" ARA was measured at rest, squeezing, and straining in 69 continent and 82 incontinent subjects all complaining of various evacuation dysfunctions. The two groups were homogeneous with regard to sex distr...

journal_title：International journal of colorectal disease

authors： Piloni V,Fioravanti P,Spazzafumo L,Rossi B

更新日期：1999-04-01 00:00:00

abstract：:Although the cause of Crohn's disease remains obscure, considerable progress has been made in recent years in unraveling the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases. Th-1 lymphocytes seem to orchestrate the inflammation through the production of proinflammatory...

journal_title：International journal of colorectal disease

authors： Baert FJ,Rutgeerts PR

更新日期：1999-02-01 00:00:00